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Gene Networks in Animal Development and Evolution

Organized by Eric Davidson and Michael Levine

February 15-16, 2008
Irvine, CA

Meeting Overview:
Gene regulatory networks represent the genomic program for the development of animal embryos, body parts, and cell types. They incorporate the interactions of intercellular signals with regulatory genes, and of regulatory genes with one another, via the transcription factors they encode. Gene regulatory networks indicate how the A’s, C’s, G’s, and T’s of the DNA genome determine which regulatory genes will be expressed in time and space during development. This Colloquium will have four sessions. The first is devoted to gene regulatory networks that control early embryonic development. There will be a particular focus on how the embryo transforms maternally inherited spatial cues into transcriptional domains of specific developmental fate. The second session concerns later developmental processes: organogenesis, terminal fate diversification and stem cell specification. The third session is about regulatory processes in complex multigenic systems, such as chromatin domains, and large clusters of related genes. Evolution of the body plan must occur by changes in the gene networks controlling development, and the final session of the Colloquium concerns this approach to understanding the generation of diversity and novelty during animal evolution.

Video Available

Session I: GENE NETWORKS IN EARLY EMBRYONIC DEVELOPMENT

Michael Levine, University of California, Berkeley
Introduction 

Sea urchin endomesoderm gene network
Eric Davidson, California Institute of Technology

Drosophila dorsal-ventral network
Michael Levine, University of California, Berkeley

 Ascidian mesoderm gene network
Kaoru Imai, University of Kyoto

 Gene networks for somitogenesis
Oliver Pourquié, Stowers Institute for Medical Research

Hh gene network in mouse CNS
Andy McMahon, Harvard University

Session II: GENE NETWORKS IN LATER DEVELOPMENT

C. elegans vulva gene network
Paul Sternberg, California Institute of Technology

Mammalian heart gene network
Eric Olson, Southwestern Medical Center

T-cell specification network
Ellen Rothenberg, California Institute of Technology

C.elegans neuronal gene network
Oliver Hobert, Columbia University College of Physicians and Surgeons

Session III: COMPLEX CIS-REGULATORY SYSTEMS

Long-range genomic control sequences
Gary Felsenfeld, National Institutes of Health

Multigene globin locus
Frank Grosveld, Erasmus University, Rotterdam

Regulatory organization of the hox gene complex
Francois Spitz, European Molecular Biology Laboratory

Muscle genomic code
Margaret Buckingham, Institut Pasteur

The A/P patterning system
Steve Small, New York University

Session IV: REGULATORY LOGIC AND EVOLUTION

Regulatory origins of neural crest
Marianne Bronner-Fraser, California Institute of Technology

Evolution of hox gene expression
Robert Krumlauf, Stowers Institute

Evolution of terminal patterning
Patricia Simpson, Cambridge University

Regulatory evolution of limb buds
Cliff Tabin, Harvard University

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