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Links Between Recombination and Replication: Vital Roles of Recombination

Organized by Charles Radding

November 10-12, 2000
Irvine, CA

A Colloquium sponsored by the National Academy of Sciences

Recombination and an overview of the links between recombination and replication
A. John Clark, Chair

An overview of recombinational repair in prokaryotes
Michael Cox, University of Wisconsin-Madison

RecBCD and its role in intiation of recombination
Stephen Kowalczykowski, University of California, Davis

The nucleoprotein filament
Takehiko Shibata, Riken Institute

D-loops, paranemic joints, and the recognition of homology
Charles Radding, Yale University

Structure of RecA, Rad51 and RadA Filaments and Rings
Edward Egleman, University of Virgina

Enzymology of Recombination in S. cerevisiae
Patrick Sung, University of Texas Health Science Center at San Antonio

Homologous recombination in S. pombe
Gerald Smith, Fred Hutchinson Cancer Research Center

Homologous recombination and Non-homologous end joining
Stephen West, Clare Hall Laboratories

Intron mobility with or without recombination
Marlene Belfort, University of Albany

Session II: Double-strand break repair
Tomoko Ogawa, Chair

MRE11 and double-strand break repair
Tomoko Ogawa, Osaka University

MRE11 and the cellular response to DNA damage
John Petrini, University of Wisconsin

Enzymology of double-strand break repair
Martin Gellert, National Institutes of Health

DNA PK and Ku
Stephen Jackson, Wellcome/CRC Institute

Regulation of double-strand break hotspots in S. cerevisiae
Alain Nicolas, Institut Curie

Repair of DNA damage and cell-cycle checkpoints
Rodney Rothstein, Columbia University

Genetics of homologous recombination in mammalian cells
Shunichi Takeda, Kyoto University

Roles of ATM homologs for DNA metabolism
Nancy Kleckner, Harvard University

Day 2:

Session III: An overview of replication
Bruce Alberts, Chair

Enzymology of Replication in E. coli
Michael O'Donnell, Rockefeller University

Kinetic studies of replication
Steven Benkovic, Pennsylvania State University

Processivity of mammalian DNA polymerases
Jerard Hurwitz, Sloan-Kettering Cancer Center

Initiation of replication in yeast
Stephen P. Bell, Massachusetts Institute of Technology

Intermediates in replication
Nicholas Cozzarelli, University of California, Berkeley

EM Analysis of replication forks at a pyrimidine dimer
Jack D. Griffith, University of North Carolina

SOS mutagenesis
Myron Goodman, University of Southern California

Damage bypass by DNA polymerase eta
Satya Prakash, University of Texas

Session IV: Recombination, replication and mutagenesis
Gisela Mosig, Chair

Mutagenesis associated with initiation of Phage T4 replication
Gisela Mosig, Vanderbilt University

The T4 recombination filament
Scott Morrical, University of Vermont College of Medicine

Coupling of replication and recombination of Phage T4
Kenneth Kreuzer, Duke University

Multiple functions of PriA
Steven Sandler, University of Massachusetts

Origin-independent initiaion at D-loops in vitro
Kenneth Marians, Sloan-Kettering Cancer Center

Role of PriA in forming replication forks
Hiroshi Nakai, Georgetown University Medical Center

Session V: Current views of copy-choice recombination
James Haber,Chair

Chromosome instability
Richard D. Kolodner, University of California, San Diego

The interaction of DNA replication, repair and recombination in trinucleotide repeat instability
David Leach, University of Edinburgh

Multiple recombination pathways in S. cerevisiae
James Haber, Brandeis University

Break-join and copy-choice pathyways in E. coli
Susan Rosenberg, Baylor College of Medicine

RadC in double-strand break repair
Susan Lovett, Brandeis University

Recombination and replication in mammalian cells
Maria Jasin, Sloan-Kettering Institute

Session VI: Rescue of replication forks and segregation of recombined chromosomes
Robert Lloyd,Chair

Vital Role for recombination in processing aberrant replicaiton intermediates and at-risk motifs
Michael Resnick, NIEHS, NIH

RNA polymerase and rescue of replication forks
Robert Lloyd, University of Nottingham

Genetics of replication fork rescue in E. coli
B. Michel

Genetics of replication fork rescue
Philip Hanawalt, Stanford University

Resolution of dimeric chromosome produced by recombination
David Sherrat, University of Oxford

Resolution of Holliday structures vs. chromosome partition
Hideo Shinagawa, Osaka University

On the rescue of ruptured replication forks
Andrei Kuzminov, University of Oregon

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