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The Neurobiology of Pain

Organized by Ronald Dubner and Michael Gold

December 11-13, 1998
Irvine, CA

Friday, December 11
Introduction, Ronald Dubner, Colloquium Organizer

Session I: Channels
John Hunter, Department of Analgesia, Roche Bioscience, Chair and Discussion Leader

Sodium Channels and the Pathophysiology of Pain
Stephen G. Waxman, Department of Neurology, Yale University School of Medicine

TTX-R INa and Inflammatory Hyperalgesia
Michael Gold, Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School

Which Potassium Channels Keep Vagal Afferent Neurons Mellow?
Daniel Weinreich, Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine

Heat-Activated Ion Currents in Nociceptors Transduction and Sensitization
Peter McNaughton, Department of Physiology, King's College London, Discussant

Session II: Receptors
Patrick Mantyh, Department of Prev. Sciences, University of Minnesota, Chair and Discussion Leader

AMPA and Kainate Receptor Expression by DRG Neurons in Culture
Amy B. MacDermott, Department of Physiology and Cellular Biophysics and Center for Neurobiology and Behavior, Columbia University

The Role of Sensory Modality-Selective Gene Transcription in Opioid Analgesia
Edwin W. McCleskey, Vollum Institute, Oregon Health Sciences University

NMDA Receptors and Src in Synaptic Plasticity
Michael W. Salter, Programmes in Brain and Behavior and Cell Biology, Hospital for Sick Children, and Department of Physiology, University of Toronto

Receptor Expression and Regulation as Mechanisms Underlying Pain and Pain Pathology
Edward R. Perl, Department of Physiology, University of North Carolina School of Medicine, Chapel Hill, Discussant

Saturday, December 12
Michael Gold, Colloquium Organizer, Introduction
Gregory Terman, Department of Anesthesiology, University of Washington, Seattle, Tribute to John Liebeskind

Session III A: Systems and Imaging
Donna Hammond, Anesthesia and Critical Care, University of Chicago, Chair and Discussion Leader

Evidence for a Visceral Pain Pathway in the Dorsal Column of the Spinal Cord
William D. Willis, Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, Texas

The Spinal Biology in Humans and Animals of Pain States Generated by Persistent Small Afferent Input
Tony L. Yaksh, Anesthesiology Research Laboratory, University of California

Gerald Gebhart, Department of Pharmacology, University of Iowa, Discussant

Session III B: Systems and Imaging
James Campbell, Department of Neurology, Johns Hopkins University Medical School, Chair and Discussion Leader

Neuropeptides and Brainstem Pain Modulating Circuits
Howard Fields, University of California, San Francisco

Forebrain Mechanisms of Nociception and Pain: Analysis Through Imaging
Kenneth L. Casey, Neurological Service, Veterans Administration Medical Center, Ann Arbor, Michigan

What Are the Essential Cerebral Components?
M. Catherine Bushnell, McGill University, Montreal, Discussant

Session IV: Growth Factors and Cytokines
Kenneth Hargreaves, Department of Endodontics, University of Texas Health Sciences Center, Chair and Discussion Leader

Trophic Factor Regulation of Nociceptor Development
William Snider, Department of Neurology, Washington University Medical Center

Neurotrophins and Pain
Lorne M. Mendell, Department of Neurobiology and Behaviour, State University of New York at Stony Brook

Immune-to-Brain Communication: Implications for Sickness and Pain
Linda R. Watkins, Department of Psychology, University of Colorado at Boulder

Multiple Trophic Factor Influences on Nociceptive System
Stephen B. McMahon, Neuroscience Research Centre, King's College London, Discussant

Session V: Development and Plasticity
Ronald Dubner, Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Chair and Discussion Leader

Postnatal Changes in Dorsal Horn Cell Activity The Development of Spinal Sensory Processing
Maria Fitzgerald, Department of Anatomy and Developmental Biology, University College London

Signal- and Activity-Dependent Plasticity in the Somatosensory System - Unraveling the Cellular and Molecular Mechanisms of Pain
Clifford J. Woolf, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School

Cellular Mechanisms of Hyperalgesia and Morphine Tolerance and Their Interactions
David J. Mayer, Department of Anesthesiology, Medical College of Virginia

The Revolution in Pain Research
Gary Bennett, Department of Neurology, Allegheny University, Philadelphia, Discussant

John Loeser, Department of Neurological Surgery and Anesthesiology, University of Washington Medical Center, Banquet Speaker

Sunday, December 13

Session VI: Molecular Genetics
Charles Inturrisi, Department of Pharmacology, Cornell University Medical College, Chair and Discussion Leader

The Neurochemistry of Acute and Persistent Pain
Allan Basbaum, Department of Anatomy, University of California, San Francisco

Migraine Pathophysiology and Treatment Mechanisms
Michael A. Moskowitz, Department of Neurosurgery and Neurology, Massachusetts General Hospital

The Genetics of Pain and Pain Inhibition: From Mice to Molecules
Jeffrey Mogil, Department of Psychology, University of Illinois at Urbana

The Mu Opiate Receptor as a Model Gene for Individual Differences in Pain and Pain Modulation
George Uhl, National Institute on Drug Abuse, National Institutes of Health

Antisense Oligodeoxynucleotides Against the TTX-Resistant Sodium Channel, PN3, Prevent and Reverse Chronic, Inflammatory and Neuropathic Pain in the Rat
Discussant Frank Porreca, Department of Pharmacology, University of Arizona Health Sciences Center

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