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Therapeutic Vaccines: Realities of Today and Hopes for Tomorrow

Organized by Michael Sela and Maurice Hilleman

April 1-3, 2004
Washington, DC

Session I:
Michael Sela, Weizmann Institute of Science, Chair
Opening Remarks

Strategies and Mechanisms in Persistent Viral Infections
Maurice Hilleman, Merck Institute for Vaccinology

Endogenous Viruses as Persistent Infections
Reinhard Kurth, Robert Koch Institute

Gene-Based Vaccines and Immunotherapeutics
Margaret Liu, Transgene, SA

DNA Fusion Vaccines to Attack Cancer
Freda Stevenson, Southampton University Hospitals Trust

Fourth Annual Sackler Lecture: Vaccinology: Challenges and Opportunities in the 21st Century
Anthony S. Fauci, National Institute of Allergy and Infectious Diseases, NIH

Session II
Jean-François Bach, Necker Hospital, Paris, Chair

Regulatory T cells and the control of autoimmunity. An overview
Jean-François Bach, Necker Hospital, Paris

Therapeutic Vaccines in Autoimmunity
Michael Sela, Weizmann Institute of Science

Mechanism of Action of Copaxone®, in Multiple Sclerosis and its Potential for the Development of New Applications
Ruth Arnon, Weizmann Institute of Science

Autoimmune Concepts of Multiple Sclerosis as a Basis for Selective Immunotherapy: From Pipedreams to Pharmaceutical Pipelines
Reinhard Hohlfeld, Max-Planck Institute of Neurobiology

Chimerism and Tolerance in Organ Transplantation
Thomas E. Starzl, Thomas E. Starzl Transplantation Institute

Session III

Freda Stevenson, Southampton University Hospitals Trust, Chair

Functional immunomics: Micro-array analysis of IgG autoantibody repertoires predicts the future response of NOD mice to an inducer of accelerated diabetes
Irun Cohen, Weizmann Institute of Science

Regulatory Cells as Therapeutics in Type 1 Diabetes
Jeffrey Bluestone, University of California, San Francisco

Cancer-provoking Viruses
Harald zur Hausen, Deutsches Krebsforschungszentrum

Melanoma and MAGE Genes
Thierry Boon, Christian de Duve Institute of Cellular Pathology

MART Genes, Melanoma and Other Cancers
Steven Rosenberg, National Cancer Institute, NIH

Session IV
Drew Pardoll, Johns Hopkins University School of Medicine, Chair

Specific Antigen Immunotherapy in Type 1 Diabetes
Hugh McDevitt, Stanford University School of Medicine

Breaking Tolerance to Tumor Antigens
Drew Pardoll, Johns Hopkins University School of Medicine

siRNA as Potential Therapeutic Agents
Phillip Sharp, Massachusetts Institute of Technology

Unique Antigens in Cancer Vaccines
Jonathan Lewis, Ziopharm

Session V
Pamela Bjorkman, California Institute of Technology, Chair

Immunotherapy as a potential treatment for Alzheimer's Disease
JoAnne McLaurin, University of Toronto

Neurodegenerative Diseases
Michal Schwartz, Weizmann Institute of Science

Prion Pathogenesis: A Journey Through Gut, Spleen, and Nerves
Adriano Aguzzi, University Hospital Zurich, Institute of Neuropathology

A linear lattice model for polyglutamine in CAG expansion diseases
Pamela Bjorkman, California Institute of Technology

From Allergen Genes to Allergy Vaccines
Rudolf Valenta, University of Vienna Medical School

General Discussions of Infections
Cognitive, Hypersensitive and Autoimmune Diseases

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