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Sackler Colloquia Logo

Gene Networks in Animal Development and Evolution
Organizered by Eric Davidson and Michael Levine,  this meeting was held on February 15-16, 2008 at the Arnold and Mabel Beckman Center in Irvine, CA. 

Meeting Overview:
Gene regulatory networks represent the genomic program for the development of animal embryos, body parts, and cell types. They incorporate the interactions of intercellular signals with regulatory genes, and of regulatory genes with one another, via the transcription factors they encode. Gene regulatory networks indicate how the A’s, C’s, G’s, and T’s of the DNA genome determine which regulatory genes will be expressed in time and space during development. This Colloquium will have four sessions. The first is devoted to gene regulatory networks that control early embryonic development. There will be a particular focus on how the embryo transforms maternally inherited spatial cues into transcriptional domains of specific developmental fate. The second session concerns later developmental processes: organogenesis, terminal fate diversification and stem cell specification. The third session is about regulatory processes in complex multigenic systems, such as chromatin domains, and large clusters of related genes. Evolution of the body plan must occur by changes in the gene networks controlling development, and the final session of the Colloquium concerns this approach to understanding the generation of diversity and novelty during animal evolution.

To view the slide and audio recordings, click on the presentation title.

Session I: GENE NETWORKS IN EARLY EMBRYONIC DEVELOPMENT

Michael Levine (University of California, Berkeley) Introduction  

Eric Davidson (California Institute of Technology) Sea urchin endomesoderm gene network.

Michael Levine (University of California, Berkeley) Drosophila dorsal-ventral network.

Kaoru Imai (University of Kyoto) Ascidian mesoderm gene network.

Oliver Pourquié (Stowers Institute for Medical Research) Gene networks for somitogenesis.

Andy McMahon (Harvard University) Hh gene network in mouse CNS.

Session II: GENE NETWORKS IN LATER DEVELOPMENT

Paul Sternberg (California Institute of Technology) C. elegans vulva gene network.

Eric Olson (Southwestern Medical Center) Mammalian heart gene network.

Ellen Rothenberg (California Institute of Technology) T-cell specification network.

Oliver Hobert (Columbia University College of Physicians and Surgeons) C.elegans neuronal gene network.

Session III: COMPLEX CIS-REGULATORY SYSTEMS

Gary Felsenfeld (National Institutes of Health) Long-range genomic control sequences.      

Frank Grosveld (Erasmus University, Rotterdam) Multigene globin locus.

Francois Spitz (European Molecular Biology Laboratory) Regulatory organization of the hox gene complex. 

Margaret Buckingham (Institut Pasteur) Muscle genomic code. 

Steve Small (New York University)  The A/P patterning system.

Session IV: REGULATORY LOGIC AND EVOLUTION

Marianne Bronner-Fraser (California Institute of Technology) Regulatory origins of neural crest.  

Robert Krumlauf (Stowers Institute) Evolution of hox gene expression.

Patricia Simpson (Cambridge University) Evolution of terminal patterning.         

Cliff Tabin (Harvard University) Regulatory evolution of limb buds.  

 

View Presentations from Recent Colloquia:

Evolution in Health and Medicine

In the Light of Evolution III: Two Centuries of Darwin

Biogeography, Changing Climates and Niche Evolution

Related Links:
Completed Colloquia 
Annual Sackler Lectures
Arthur M. Sackler Biography 

Proceedings of the National Academy of Sciences
National Academies Press Publications

 

Arthur M. Sackler Colloquia
of the National Academy of Sciences
100 Academy
Irvine, CA 92617
949.721.2213
sackler@nas.edu

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