|
Microbes and Health
Organized by Jeffrey Gordon and Todd Klaenhammer, this meeting was held at the Beckman Center in Irvine, CA on November 2-3, 2009. This colloquium focused on characterization of the foundations of host-microbial symbioses, primarily in the human. Given the remarkable growth of the field of metagenomics, and the astonishing proliferation of human microbiome initiatives in many nations, it was timely to convene a colloquium that examined the assembly, composition, functions and dynamic operations of body habitat-associated microbial communities. The microbiota plays many important roles in maintaining health and in promoting various diseases and this colloquium discussed the experimental and computational approaches that are being, and need to be, deployed to comprehensively characterize our microbiome in health and disease, and interventional strategies that may be useful for its deliberate manipulation.
This meeting was co-sponsored by the International Scientific Association for Probiotics and Prebiotics (ISAPP) and was followed by their Annual meeting on November 4-5.
Recordings of presentations will be posted as they are received and approved by the speakers. In some cases, as-yet unpublished, embargoed data may be edited from the recording at the speaker's request.
*Click on the ipod icon to download on itunes or your ipod
Monday, November 2, 2009
Opening Addresses
Session Chair: Jeffrey Gordon, Washington University School of Medicine
Nancy Moran, University of Arizona, Evolution of biological complexity and symbiosis
Session I: Setting the Stage
Rob Knight, University of Colorado, Boulder, The 16S rRNA renaissance: computational and experimental perspectives
Jonathan A. Eisen, University of California, Davis, Looking at the tree of life
Elaine Holmes, Imperial College London, An integrated systems biology view of host-microbial interactions
Elaine Vaughan, Unilever Research & Development, Approaches to study bioconversion of dietary polyphenols by gut microbiota
Bart Keijser, TNO, Exploring the oral microbial diversity using the OC chip
Joel Dore, INRA, Metagenomic studies of the human gut
Forest Rohwer, San Diego State University, Viral diversity in human and non-human habitats
David Relman, Stanford University, Antibiotics: a tool to probe ecosystem robustness and diversity
Session II: Case studies
Michiel Kleerebezem, Wageningen University, Monitoring transcriptional responses in the human gut to the microbiota
Karen Guillemin, University of Oregon, Using gnotobiotic zebrafish to dissect the foundations of host-microbial interactions
Ruth Ley, Cornell University, A deeper look into maternal programming of the infant gut microbiota
Paul O'Toole, University College Cork, Gut microbiota of the elderly - The ELDERMET Consortium
Fredrik Backhed, University of Gothenburg, Tissue factor promotes microbiota-induced angiogenesis in the gut
Tuesday, November 3, 2009
Session III: Interactions between microbial communities and the immune system
Jerry Wells, Wageningen University, Intestinal homeostasis and the role of innate recognition of microbes at the epithelial surface
Sarkis Mazmanian, California Institute of Technology, Innate immune responses to commensal bacteria
Wendy Garrett, Harvard University, Lessons about the interplay between the immune system and the microbiota
Ramnik Xavier, Harvard University, A systems biology view of host-microbial interactions in IBD
Colin Hill, University College Cork, Antimicrobials and potential modification of microbiota
Jens Walter, University of Nebraska, Evolution of the gut symbiont Lactobacillus reuteri
Alan Huett, Massachusetts General Hospital, An automated screen of secreted bacterial effector proteins to identify modulators of mammalian autophogy
http://sackler.nasmediaonline.org/2009/microbes/karen_scott/karen_scott.mp4Session IV: Glycobiology redux
David Mills, University of California, Davis, The human glycobiome and its impact on the infant microbiota
Gunnar C. Hansson, University of Gothenburg, Mucus - a legislator of host-microbial interactions
Dennis Kasper, Harvard University, Cell surface glycans as therapeutic agents
Session V: Manipulations of the microbiota
Karen Scott, University of Aberdeen, Impact of dietary manipulations on human microbial ecology and health
Larry Forney, University of Idaho, The vagina microbiome and microbiota
Gregor Reid, University of Western Ontario, Clinical manifestations of the vaginal microbiota in health or disease
Closing address
Todd Klaenhammer and Jeffrey Gordon, Closing comments and moving forward
|
