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Evolution in Health and Medicine
Organized by Peter Ellison, Diddahally R. Govindaraju, Randolph M. Nesse and Stephen C. Stearns, this meeting was held April 2-3, 2009 at the National Academy of Sciences, Washington, D.C.
Listen to an interview by organizer Peter Ellison.
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Evolution, genetics and medicine share a long and distinguished tradition. Although evolutionary biology and genetics merged during the Modern Synthesis of the mid- 20th century, medicine has remained isolated from the evolutionary half of the synthesis. This is somewhat surprising, given that the foundations for much of the present day medical and human genetics, were laid by the evolutionary insights of pioneering physicians long before DNA's functions were understood. Many medical applications of evolutionary biology are only now being recognized. This colloquium will include evolutionary biologists, physician scientists, human geneticists and biologists, epidemiologists, veterinary scientists and ethicists who are working towards an interdisciplinary synthesis that will bring the full power of evolutionary biology to bear in medicine, public health and related fields devoted to human and animal health and welfare.
To view presentations, click on the title. A link to each speaker's website is available by clicking the speaker's name.
Introduction, Peter Ellison (Harvard University)
Overview of Evolutionary Applications in Medicine, Randolph Nesse (University of Michigan)
Session I: Evolutionary Genetics in Human Health
A. Genome Architecture and Natural Selection
Chair: Barbara Schaal (Washington University in St. Louis)
Genome Architecture in Human Health, Michael Lynch (Indiana University)
Reproductive Ecology and Reproductive Health, Peter Ellison (Harvard University)
Phenotypic Selection, David Houle (Florida State University)
B. Genetic and Epigenetic Factors
Chair: Diddahally Govindaraju (Boston University)
Mutational Load and Health, Adam Eyre-Walker (University of Sussex)
Genomic Rearrangements and Copy Number Variations, James Lupski (Baylor College of Medicine)
Epigenetics, Evolution and Disease, Andrew Feinberg (Johns Hopkins University)
Session II: Development, Demography, and Disease
Chair: Stephen Stearns (Yale University)
Dissecting the Genetic Architecture of Human Fertility Traits, Carole Ober (University of Chicago)
Intergenerational Transfers and the Evolution of the Human Life Cycle, David Haig (Harvard University)
The Evolution of Contemporary Human Health, Stephen Stearns (Yale University)
Evolution and Aging and Age Related Disorders, Caleb Finch (University of Southern California)
Session III: Gene by Environment Interactions and Complex Diseases
Chair: Peter Ellison (Harvard University)
Evolutionary Pathways of Drug Resistance, Daniel Hartl (Harvard University)
Evolution and Cancer, Steven Frank (University of California, Irvine)
Inbreeding, Human Evolution, and Complex Diseases, Alan Bittles (Edith Cowan University)
Annual Sackler Public Lecture
Introduction, Ralph Cicerone, President, National Academy of Sciences
Evolution and the Future of the Earth, Edward O. Wilson (Harvard University)
Session IV: Co-Evolution of Pathogen and Hosts
Chair: Jeffrey Flier (Harvard University)
The Emergence and Evolution of Viral Pathogens, Edward Holmes (Pennsylvania State University)
The Evolution of Pathogen Resistance, Carl Bergstrom (University of Washington)
Evolution and the Immune System, Christopher Dascher (Mount Sinai School of Medicine)
Coevolution of Parasites and Immunity, Kathleen Barnes (Johns Hopkins University)
Session V. Evolution, Mental health and Therapeutics
Chair: Randolph Nesse (University of Michigan)
Environment and Neurodevelopmental Disorders, Ezra Susser (Columbia University)
The Genomic and Cognitive Architecture of Autism and Psychosis, Bernard Crespi (Simon Fraser University)
Genomic Analysis of Schizophrenia Guided by an Evolutionary Model, Mary-Claire King (University of Washington)
Keynote Address: Evolution, Health and Medicine, Harvey Fineberg, President, Institution of Medicine
Session VI: Changing Future Trajectories for Evolution in Medicine and Public Health
Chair: Mary-Claire King (University of Washington)
Bringing Evolutionary Biology into Medical Education, Jeffrey Flier (Harvard University), Peter Gluckman (University of Auckland), Mark Schwartz (NYU)
Policy Recommendations and Final Thoughts, Gilbert Omenn (University of Michigan), Randolph Nesse (University of Michigan), David Valle (Johns Hopkins University)
Summary of the Meeting, Stephen Stearns (Yale University)
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