Pablo Debenedetti is the Class of 1950 Professor in Engineering and Applied Science and Dean for Research at Princeton University. His research interests include the thermodynamics and statistical mechanics of liquids and glasses; water and aqueous solutions; protein thermodynamics; nucleation; metastability; and the origin of biological homochirality. Debenedetti?s honors include the NSF’s Presidential Young Investigator Award (1987); the Camille and Henry Dreyfus Teacher-Scholar Award (1989); a Guggenheim Memorial Foundation Fellowship (1991); the AIChE?s Professional Progress (1997), Walker (2008), Institute Lecture (2013) and Alpha Chi Sigma (2019) awards; the J. M. Prausnitz Award in Applied Chemical Thermodynamics (2001); the ACS’s Hildebrand Award in the Theoretical and Experimental Chemistry of Liquids (2008); and the Institution of Chemical Engineers’s Guggenheim Medal (2017). He received the President’s Award for Distinguished Teaching (2008), Princeton’s highest distinction for teaching. In 2008 Debenedetti was named one of 100 Chemical Engineers of the Modern Era by the AIChE. He is a member of the National Academy of Engineering, the American Academy of Arts and Sciences, and the National Academy of Sciences, and a fellow of AAAS, AIChE and APS.

Research Interests

My current research includes theoretical and computational investigation of metastable criticality in water; computational analysis of the long-range structure of water glasses; development of genetic algorithms for the optimization of protein anti-freeze activity; advanced sampling computational investigation of DNA hybridization and RNA folding; and theoretical and computational investigation of chirality-induced liquid-liquid phase transitions.

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Primary Section

Section 31: Engineering Sciences

Secondary Section

Section 33: Applied Physical Sciences