Ira Pastan

National Institutes of Health

Primary Section: 41, Medical Genetics, Hematology, and Oncology
Secondary Section: 42, Medical Physiology and Metabolism
Membership Type:
Member (elected 1982)

Research Interests

My interest is in developing new therapies for cancer by making fusion proteins composed of the Fv portion of antibodies directed at antigens on cancer cells fused to a genetically modified form of a powerful bacterial toxin, Pseudomonas exotoxin A. These chimeric proteins which are termed recombinant immunotoxins are being tested in humans with various forms of cancer. I also study the human multidrug resistance gene, MDR1, and how this resistance gene can be used in gene therapy.

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