E. Dale Abel
University of California, Los Angeles
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Primary Section: 42, Medical Physiology and Metabolism Secondary Section: 23, Physiology and Pharmacology Membership Type:
Member
(elected 2022)
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Biosketch
E. Dale Abel is a distinguished endocrinologist recognized for his pioneering studies in metabolic regulation in the cardiovascular system, mitochondrial biology and insulin signaling. He elucidated mitochondrial mechanisms contributing to heart failure in diabetes, metabolic mechanisms increasing thrombosis in diabetes and metabolic signals that regulate cardiac hypertrophy. Abel was born in Jamaica and attended Wolmer's High School for Boys. He completed his medical degree from the University of the West Indies in Kingston, Jamaica, being the first to receive the MB.BS degree with distinction and obtained a DPhil in physiology from Oxford University in 1991, as a Rhodes Scholar. He trained in internal medicine at Northwestern and in endocrinology at Harvard. Abel has held endowed professorships at the U of Utah, the U of Iowa and at UCLA. He has received numerous awards for contributions to research including the Innovator Award of the ISHR, the Arnold Katz Award of the Sarnoff Cardiovascular Research Foundation and the Gerald D. Aurbach Award of the Endocrine Society. Abel is an elected member of the American Association of Physicians (AAP), the American Society for Clinical Investigation (ASCI), National Academy of Medicine (NAM), and the American Clinical and Climatological Association (ACCA). He is a past President of the Endocrine Society and the Association of Professors of Medicine (APM).
Research Interests
The Abel laboratory has provided important insights into the contribution of mitochondrial dysfunction and aberrant insulin signaling to heart failure risk in diabetes. Recent work has focused on mitochondrial mechanisms that mediate inter-organ crosstalk and influence the pathophysiology of insulin resistance, and mitochondrial pathways linking metabolism with increased risk for atherothrombosis.
