Organized Collections

Committees on Drug Addiction, Drug Addiction (Advisory), and Drug Addiction & Narcotics, 1928-1965

[The following history of the National Research Council committees examining various problems of drug addiction was adapted from an account produced by the Research Council’s Division of Medical Sciences in 1969.]

The roots of the National Research Council’s various committees on drug addiction, dependence and narcotics reach back to a Committee on Drug Addictions established in 1921 by the Bureau of Social Hygiene, Inc., of New York City. The objective of this group was to combine professional and lay educational programs in the use and abuse of narcotic drugs with efforts to stimulate the search for agents with little or no addiction liability that might be substituted for opium derivatives in medical practice.

The Bureau soon realized its limitations in the promotion of research and, in 1929, invited the Division of Medical Sciences of the National Research Council to assume responsibility for this endeavor. The Division appointed its own Committee on Drug Addiction which developed plans for a coordinated program of chemical, pharmacological and clinical investigations. The Committee was instrumental in establishing and supporting a chemical laboratory at the University of Virginia and a pharmacological laboratory at the University of Michigan with funds provided by the Bureau of Social Hygiene and the Rockefeller Foundation. The Committee also enlisted the cooperation of the US Public Health Service Narcotics Hospital at Lexington, Kentucky for the clinical study of compounds produced and characterized by these two laboratories. Over a period of eleven years, several hundred morphine-related compounds were prepared and tested. A few came to clinical trial but only one, Metapon, was ever marketed.

In 1938, the Public Health Service established a Division of Chemotherapy at the National Institutes of Health, and in 1939 the National Research Council agreed to transfer the programs at the Universities of Virginia and Michigan to this new unit. The Research Council committee continued to serve in an advisory capacity.

The Advisory Committee on Drug Addiction was relatively inactive during the Second World War, but was reconstituted in 1947 as the Committee on Drug Addiction and Narcotics. In 1965, its name was again changed, this time to the Committee on Problems of Drug Dependence. The new name was intended to reflect its broader interest in all types of drugs that produce dependence.

It immediately became evident to the Committee on Drug Addiction and Narcotics that the wartime success of German laboratories in producing new synthetic, morphine-like analgesic agents, including meperidine and methadone, was stimulating a lively response from the pharmacological industry in the United States. The anticipated flood of new drugs threatened to overwhelm the limited resources of the hospital at Lexington and urgently called for the development of methods for the screening of drugs to identify those that were of considerable promise. An appeal was made to the industry, and thirteen firms responded with funds that helped the Committee initiate two projects. The first, undertaken at the Harvard Medical School, was concerned with the clinical evaluation of the analgesic effectiveness of new drugs submitted to the Committee. The second, at the University of Michigan, was for the development of a regimen for the assay of the dependence liability of these drugs in monkeys.

In making its awards, the Committee critically evaluated the design of each study and its pertinence to the overall objective of the program. It assigned new drugs to appropriate laboratories, and, on the basis of the cumulative data on any given drug, decided whether the toxicological, pharmacological and clinical results justified screening for drug dependence first in the monkey, at the University of Michigan, and, on the basis of these results, in man at the Drug Addiction Research Center, PHS, at Lexington, Kentucky. Only when information from all of these screening stages was obtained and evaluated would the Committee submit to the Food and Drug Administration, the Bureau of Narcotics and Dangerous Drugs, and the World Health Organization recommendations with respect to the national and international control of traffic in the drug in question.

The records of the National Research Council’s Committee on Drug Addiction, Advisory Committee on Drug Addiction, and Committee on Drug Addiction and Narcotics cover the years 1928-1969 and contain correspondence, reports, meeting minutes, and other materials, spanning approximately six feet.

COMMITTEE ON DRUG ADDICTION, 1928-1941 (Location: Mezzanine G-4-1)
Series 1: Administration
Series 2: Files of the Committee on Drug Addiction
Series 3: Financial Records
Series 4: Government Agencies

COMMITTEE ON DRUG ADDICTION, Advisory, 1941-1947 (Location: Mezzanine G-4-2)
Series 1: Records of Committee on Drug Addiction, Advisory
Series 2: Financial Records
Series 3: Government Agencies

COMMITTEE ON DRUG ADDICTION & NARCOTICS, 1947-1965 (Location: Mezzanine G-4-2 & 3)
Series 1: Committee Correspondence Files
Series 2: Committee Meeting Minutes
Series 3: Alphabetical & Miscellaneous Subject Files
Series 4: Correspondence with Drug Manufacturers
Series 5: Financial Files
Series 6: Government Agencies

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COMMITTEE ON DRUG ADDICTION, 1928-1941

Location: Mezzanine G-4-1

Series 1: Administration

Fellowships: 1931-1939

Institutions Associations Individuals: American Medical Association (AMA): General: 1929-1932

Institutions Associations Individuals: Bureau of Social Hygiene: Committee on Drug Addictions: Report of Activities 1921-1928: 1928

Institutions Associations Individuals: Bureau of Social Hygiene: Committee on Drug Addictions: Termination of Activities: 1928-1930

Institutions Associations Individuals: General: 1935-1939

Legal Matters: Patents: Policy re Committee on Drug Addiction Patents: Conference on Disposition of Narcotics Patents: Jt w Committee on Patent Policy: 1936-1937

Legal Matters: Patents: Policy re Committee on Drug Addiction Patents: Conference on Disposition of Narcotics Patents: 1933-1938

Legal Matters: Patents: Small L F: Ethers of Morphine & Dihydromorphine & Their Respective N-oxides: 1936-1938

Legal Matters: Patents: Small L F: Ethers of Morphine & Its Dihydrogenated Derivative & Methods of Production: 1935-1936

Legal Matters: Patents: Small L F: Morphine Derivatives & Processes for Their Preparation: 1933-1938

Legal Matters: Patents: Small L F & Fitch H M: Nuclear Substituted Derivatives of Morphine Series & Methods for Their Preparation: Foreign Patents: German: 1937-1939

Legal Matters: Patents: Small L F & Fitch H M: Nuclear Substituted Derivatives of Morphine Series & Methods for Their Preparation: Foreign Patents: General: 1936-1939

Legal Matters: Patents: Small L F & Fitch H M: Nuclear Substituted Derivatives of Morphine Series & Methods for Their Preparation: US: 1937-1939

Publications: 1931-1939

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Series 2: Files of the Committee on Drug Addiction

Appointments: Members: 1928-1938

Assistance to Outside Investigators: Anthropoid Experiment Station: 1934-1937

Assistance to Outside Investigators: Fourneau E: 1936-1937

Assistance to Outside Investigators: General: 1934-1938

Beginning of Program: 1928-1929

Conferences: 1936

End of Program: 1941

Final Report & Collected Reprints 1930-1941: 1941

Grantees: 1929-1939

Grantees: Geiling E M K: 1940-1941

Grantees: Hamlin E: 1940

Grantees: Wright C I: 1940-1941

Meetings: Minutes: 1933-1939

Meetings: Minutes: 1930-1932

Meetings: Minutes: 1929

Miscellaneous Papers: 1930-1940

Policy: 1929-1939

Projects: Development of Nonaddictive Analgesics: Chemical Synthesis: U of Virginia: Establishment of Research Unit: 1929

Projects: Development of Nonaddictive Analgesics: Chemical Synthesis: U of Virginia: Preparation Reports: 1930-1939

Projects: Development of Nonaddictive Analgesics: Chemical Synthesis: U of Virginia: General: 1930-1939

Projects: Development of Nonaddictive Analgesics: Chemical Synthesis: Yale U: 1929-1939

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Beginning of Program: 1931-1932

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Conferences: 1940

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Conferences: 1939

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Conferences: 1938

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Conferences: 1936

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Conferences: General: 1940-1941

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Leavenworth Penitentiary Annex: 1932-1934

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Marine Hospital: 1938-1939

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Massachusetts Dept of Public Health: Pondville Hospital: 1934-1939

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Massachusetts Dept of Public Health: General: 1938-1939

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Massachusetts General Hospital: 1939

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Middlesex County Sanitarium: 1934-1939

Projects: Development of Nonaddictive Analgesics: Clinical Studies: New York: Proposed: 1932

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Public Health Service Hospital: Lexington: Symposium on Drug Addiction: 1936

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Public Health Service Hospital: Lexington: General: 1932-1939

Projects: Development of Nonaddictive Analgesics: Clinical Studies: U of Michigan Hospital: 1935-1938

Projects: Development of Nonaddictive Analgesics: Clinical Studies: Walter Reed General Hospital: 1937-1939

Projects: Development of Nonaddictive Analgesics: Drugs: Dihydrodesoxymorphine-D (Desomorphine): 1934-1937

Projects: Development of Nonaddictive Analgesics: Drugs: Dilaudid: 1932-1939

Projects: Development of Nonaddictive Analgesics: Drugs: Dolantin: 1940-1941

Projects: Development of Nonaddictive Analgesics: Drugs: Metapon (Methyldihydromophinone): Commercial Development: 1940-1941

Projects: Development of Nonaddictive Analgesics: Drugs: Metapon (Methyldihydromophinone): Commercial Development: 1937-1939

Projects: Development of Nonaddictive Analgesics: Drugs: Metapon (Methyldihydromophinone): General: 1938-1939

Projects: Development of Nonaddictive Analgesics: Drugs: Studies: Proposed: 1937-1939

Projects: Development of Nonaddictive Analgesics: Fellowships: E R Squibb & Sons: 1932-1939

Projects: Development of Nonaddictive Analgesics: Fellowships: Mallinckrodt & Co: 1933-1939

Projects: Development of Nonaddictive Analgesics: Fellowships: Merck & Co: 1933-1939

Projects: Development of Nonaddictive Analgesics: Pharmacologic Testing: U of Michigan: Establishment of Research Unit: 1929-1930

Projects: Development of Nonaddictive Analgesics: Pharmacologic Testing: General: 1930-1938

Projects: Development of Nonaddictive Analgesics: Progress Reports: 1934-1938

Projects: Development of Nonaddictive Analgesics: Progress Reports: 1930-1933

Projects: Development of Nonaddictive Analgesics: Provision of Drugs to Research Units: 1929-1939

Projects: Development of Nonaddictive Analgesics: Reports: Studies on Drug Addiction: 1937-1938

Projects: Development of Nonaddictive Analgesics: Transfer of Chemical & Pharmacologic Work to US Public Health Service (USPHS): 1938-1939

Projects: Development of Nonaddictive Analgesics: General: 1932-1938

Projects: Education of Physicians: Jt w American Medical Association (AMA): Articles on Indispensable Use of Narcotics: 1929-1932

Projects: Education of Physicians: Jt w American Medical Association (AMA): Indispensable Use of Narcotics: Compilation: 1931

Projects: Effects of Drug Addiction on Chimpanzees: Jt w Anthropoid Experiment Station: 1933-1934

Projects: Surveys of Literature: Chemistry of Opium Alkaloids: Small L F: 1929-1936

Projects: Surveys of Literature: Pharmacology of Opium Alkaloids: Hatcher R A: 1929-1931

Projects: Surveys of Literature: Pharmacology of Opium Alkaloids: Krueger H Eddy N B & Sumwalt M: Parts 1 & 2: 1941 & 1943

Projects: Surveys of Literature: Pharmacology of Opium Alkaloids: Manuscript: Hatcher R A: 1931

Projects: Surveys of Literature: Pharmacology of Opium Alkaloids: U of Michigan: 1940

Projects: Surveys of Literature: Pharmacology of Opium Alkaloids: U of Michigan: 1931-1939

Projects: General: 1930-1936

Reports: 1940-1941

Reports: 1933-1939

Reports: 1929-1932

Requests for Support: Bureau of Social Hygiene: 1929-1933

Requests for Support: Rockefeller Foundation: 1940-1941

Requests for Support: Rockefeller Foundation: 1931-1939

Requests for Support: General: 1932-1939

Statement of Program & Work in Progress: 1930-1931

General: 1940-1941

General: 1929-1939

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Series 3: Financial Records

Finance: Funds: Grants: Bureau of Social Hygiene: 1929-1932

Finance: Funds: Grants: Rockefeller Foundation: 1931-1939

Finance: Funds: Grants: General: 1932-1939

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Series 4: Government Agencies

Agencies & Departments: Treasury: Public Health Service: Bureau of Narcotics: 1930-1938

Agencies & Departments: Treasury: Public Health Service: Conference on Investigation of US Narcotic Drug Requirements: Aug 1930

Agencies & Departments: Treasury: Public Health Service: Division of Mental Hygiene: 1930-1936

Agencies & Departments: Treasury: Public Health Service: General: 1929-1939

Agencies & Departments: General: 1931-1939

Congress: Acts: Creation of Bureau of Narcotics within Department of Treasury: 1930

Congress: Acts: Establishment of Two Narcotics Farms: 1928

International Relations: League of Nations: Advisory Committee on Traffic in Opium & Other Dangerous Drugs: 1940

International Relations: League of Nations: Advisory Committee on Traffic in Opium & Other Dangerous Drugs: 1936-1939

International Relations: League of Nations: Conference on Limitation of Manufacture of Narcotic Drugs: 1931

International Relations: League of Nations: Health Section: Examination of Dihydrodesoxymorphine-D: 1936-1937

International Relations: League of Nations: Health Section: Opium Assay Commission: 1937-1938

Municipal Governments: Middlesex County Sanitarium: 1935

State Governments: Commissioners on Uniform State Laws: Uniform State Narcotic Law: 1932

State Governments: Massachusetts: Department of Public Health: 1934-1935

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COMMITTEE ON DRUG ADDICTION, Advisory, 1941-1947

Location: Mezzanine G-4-2

Series 1: Records of Committee on Drug Addiction, Advisory (dark blue labels)

Appointments: Members: 1941-1945

Beginning of Program: 1941

Projects: Production & Distribution of Metapon: 1940-1946

Reports: 1942-1947

Requests for Advice & Drugs: Demerol: 1942-1944

Requests for Advice & Drugs: Manufacture of Desomorphine: 1942

Requests for Advice & Drugs: General: 1941-1947

General: 1941-1946

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Series 2: Financial Records (green label)

Grants: American Cancer Society: 1946

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Series 3: Government Agencies (red label)

General: 1940-1947

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COMMITTEE ON DRUG ADDICTION & NARCOTICS, 1947-1965

Location: Mezzanine G-4-2 & 3

Series 1: Committee Correspondence Files (dark blue labels)

Committee on Drug Addiction & Narcotics:

1960-1961

1955-1959

1950-1953

1947-1949

Activities [Excerpts from Division of Medical Sciences Annual Reports]: 1952-1954

Cameron-Eddy Correspondence: 1961-1965

General Reprints: 1954-1962

Liaison Representatives: 1960

Meetings: 21 Jun 1957

Meetings: General: 1954-1965

Membership: 1960-1964

Membership: 1959

Membership: May E L: 1961-1966

Memoranda: 1960

Name Change: Proposed: 1965

Relationships: Bureau of Narcotics [Controversy re Charge to Committee]: 1959

Report: Narcotics & Medical Practice: Joint with American Medical Association: 1963

Reports Submitted to Committee: Summaries: 1955-1959

Resolution: Applicability of Civil Commitment to Treatment of Addicts: 1960

Resolution [on Treatment]: Joint with American Medical Association: 1962

Special Drug Reports from Dr Eddy to Mr Grove: 1964

General: 1961-1965

General: 1950-1960

Committee on Problems of Drug Dependence: Cameron-Eddy Correspondence: 1966-1967

Committee on Problems of Drug Dependence: History: 1969

Committee on Problems of Drug Dependence: General 1966-1967

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Series 2: Committee Meeting Minutes (violet labels)

Committee on Drug Addiction & Narcotics: Meetings:

27th: Minutes: Feb 1965 (Houston)

26th: Minutes: Feb 1964 (Washington)

25th: Minutes: Volumes I: Feb 1963 (Ann Arbor)

25th: Minutes: Volume II: Feb 1963 (Ann Arbor)

24th: Minutes: Jan 1962 (NY)

24th: Minutes: Addenda: Jan 1962 (NY)

23rd: Minutes: Jan 1961 (NY)

23rd: Minutes: Addenda: Jan 1961 (NY)

22nd: Special: Minutes: Apr 1960 (Washington)

21st: Minutes: Jan 1960 (Philadelphia)

21st: Minutes: Addenda: Jan 1960 (Philadelphia)

20th: Minutes: Jan 1959 (Washington)

19th: Minutes: Mar 1958 (Washington)

18th: Minutes: Jan 1957 (Indianapolis)

17th: Minutes: Jan 1956 (Washington)

16th: Minutes: Sep-Oct 1955 (Bethesda)

15th: Minutes: Jan 1955 (Lexington)

14th: Minutes: Oct 1954 (Rensselaer, NY)

13th: Minutes: Jan 1954 (NJ & NY)

12th: Minutes: Nov 1953 (Boston)

11th: Minutes: Jan 1953 (Lexington)

10th: Minutes: Jun 1952 (Ann Arbor)

9th: Minutes: Jan 1952 (Washington)

8th: Minutes: Jun 1951 (Washington)

7th: Minutes: Jan 1951 (Washington)

6th: Minutes: Mar 1950 (Washington)

5th: Minutes: Nov 1949 (Washington)

Conference with Representatives of Drug Manufacturers: Jul 1949 (Washington)

4th: Minutes: Oct 1948 (Lexington)

3rd: Minutes: May 1948 (Washington)

2nd: Minutes: Jan 1948 (Washington)

1st: Minutes: Oct 1947 (Washington)

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Series 3: Alphabetical & Miscellaneous Subject Files (white labels)

“C” Miscellaneous: 1963-1964

“D” Miscellaneous: 1965-1966

“F” Miscellaneous: 1965-1966

“G” Miscellaneous: 1964-1966

“I” Miscellaneous: 1962-1965

“J” Miscellaneous: 1962-1966
“K” Miscellaneous: 1965-1967

“L” Miscellaneous: 1961-1967

“M” Miscellaneous: 1961-1967

“N” Miscellaneous: 1961-1966

“O” Miscellaneous: 1965

“P” Miscellaneous: 1962-1967

“R” Miscellaneous: 1963-1967

“S” Miscellaneous: 1955-1966

“U” Miscellaneous: 1961-1964

“W” Miscellaneous: 1951-1967

Abuse of LSD: 1966-1967

Alcoholism & Drug Addiction Research Foundation [Polaczek]: 1962-1967

American Medical Association (AMA): 1963

Foreign Correspondence: 1960-1967

Huntley H C [re Levoprome]: 1967

Quinn W F: 1963

Sadove M S: U of Illinois: 1961-1962

United Nations: European Office [Braenden]: 1960-1966

Varenne G: 1961-1966

World Health Organization [Halbach]: 1961-1966

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Series 4: Correspondence with Drug Manufacturers (yellow labels)

A H Robins Co: 1961-1968

Abbott Laboratories: 1962-1967

Bristol Laboratories Inc: 1961-1967

Bristol-Myers Product Division: 1961-1966

Burroughs Wellcome & Co: 1965-1966

Charles E Frost & Co: 1961-1966

Chas Pfizer & Co: 1961-1965

CIBA Pharmaceuticals: 1961-1967

Edinburgh Pharmaceutical: 1961-1964

Endo Laboratories Inc: 1961-1967

Endo Laboratories Inc: For submission to Feb 1968 meeting: 1968

G D Searle & Co: 1961-1967

Geigy Research Laboratories: 1961-1967

Hoffman-La Roche: 1961-1966

J F Macfarlan & Co Ltd (Scotland UK): 1961-1963

Knoll Pharmaceuticals: 1961-1967

Lederle Laboratories: 1961-1967

Lilly Research Laboratories: 1960-1969

Macfarlan-Smith Ltd (Scotland UK): 1965-1966

Mallinckrodt Chemical Works: 1961-1966

McNeil Laboratories: 1962-1967

Mead Johnson Research Laboratories: 1961-1966

Merck & Co [Merck Sharp, and Dohme]: 1961-1967

Miles-Ames Research Laboratory: 1960-1966

National Drug Co: 1961-1967

Reckitt & Sons Ltd: 1964-1967

Riker Laboratories: 1961-1967

S B Penick & Co: 1961-1967

Schering Corp: 1961-1967

Smith Kline & French Laboratories: 1961-1967

Squibb Institute: 1961-1967

Sterling-Winthrop Research Institute: 1965-1966

Sterling-Winthrop Research Institute: 1961-1964

Strasenburgh Laboratories: 1960-1962

T H Smith [See Edinburgh Pharmaceutical folder]

Upjohn Company: 1962-1967

Vick Chemical Co: 1961-1967

Wallace Laboratories: 1961-1967

Warner-Lambert Research Institute: 1961-1967

Winthrop Laboratories: 1961-1967

Wm S Merrell Co: 1961-1967

Wyeth Laboratories: 1961-1967

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Series 5: Financial Files (green labels)

Expenditures & Commitments: 1952-1966

Grantees: Aston R: 1963-1967

Grantees: Beecher H K: 1955-1965

Grantees: Beecher H K: 1953-1954

Grantees: Beecher H K: 1949-1952

Grantees: Bellville J W: 1961-1963

Grantees: Cass L J: 1958-1966

Grantees: Lee L E: 1954-1969

Grantees: Seevers M: 1950-1959

Grants: 1 Jul 1964 - 30 Jun 1965: 1965

Grants: 1 Jul 1963 – 30 Jun 1964: 1964

Grants: 1 Jul 1962 - 30 Jun 1963: 1963

Grants: 1 Jul 1961 - 30 Jun 1962: 1962

Grants: 1 Jul 1960 - 30 Jun 1961: 1961

Grants: 1 Jul 1959 - 30 Jun 1960: 1960

Grants: 1 Jul 1958 - 30 Jun 1959: 1959

Grants: 1 Jul 1957 - 30 Jun 1958: 1958

Grants: 1 Jul 1956 - 30 Jun 1957: 1957

Grants: 1 Jul 1955 - 30 Jun 1956: 1956

Grants: 1 Jul 1954 - 30 Jun 1955: 1955

Grants: 1 Jul 1953 - 30 Jun 1954: 1954

Grants: 1 Jul 1952 - 30 Jun 1953: 1953

Listing of Grants Awarded by Committee on Drug Addiction & Narcotics: 1950-1963

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Series 6: Government Agencies (red labels)

Bureau of Narcotics: Advisory Committee to Commissioner of Narcotics: 1960-1961

Bureau of Narcotics: Drugs Disposal Committee: 1961-1965

Bureau of Narcotics: Title 21: 1961

Bureau of Narcotics: General: 1951-1965

Canada Food & Drug Directorate: 1962-1964

Japan-US Cooperative Science Program: Research on Narcotic & Drug Abuse: 1964-1965

Judicial Conference of DC Circuit: Committee on Laws Pertaining to Mental Disorders: 1964-1965

National Institute of Mental Health: Development of Chemical Test for Narcotic Excretion: 1960

National Institute of Mental Health: USPHS Hospital: Lexington: 1961-1967

National Institute of Mental Health: USPHS Hospital: Lexington: Fraser H F: 1961-1963

National Institute of Mental Health: USPHS Hospital: Lexington: Isbell H: 1961-1962

New York City: 1961-1966

New York State: 1961

President’s Advisory Commission on Narcotic & Drug Abuse: 1963

President’s Commission on Law Enforcement & Administration of Justice: 1966

Veterans Administration: Cooperative Study on Evaluation of Narcotics & Analgesics: 1962-1965

White House Conference on Narcotic & Drug Abuse: 1962

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