E. R. Stadtman
National Institutes of Health
November 15, 1919 - January 7, 2008
Election Year: 1969
Scientific Discipline: Biochemistry
Membership Type: Member
Enzymologist E.R. Stadtman studied substrate activation via coenzymes. He discovered the role coenzyme A plays in fatty acid oxidation and outlined the mechanism of acetoacetyl CoA synthesis; essential for the production of cholesterol. In addition, he studied glutamine synthetase in E. coli and found its activity was controlled by a phosphorylation cascade system that was feedback-dependent on metabolite levels.
Stadtman earned his B.S. and PhD from the University of California, Berkeley and became an AEC fellow at Massachusetts General Hospital. In 1950, he began his long career at the National Institutes of Health, where he served as Chemist at the National Heart Institute, Chief of the Enzyme Section, and Laboratory Chief. President Jimmy Carter awarded Stadtman the National Medal of Science in 1979 for his work on anaerobic bacteria and the interpretation of metabolic rates within a living cell