Linda J. Saif

The Ohio State University


Election Year: 2003
Primary Section: 61, Animal, Nutritional, and Applied Microbial Sciences
Secondary Section: 44, Microbial Biology
Membership Type: Member

Research Interests

As a virologist and immunologist, my research focuses on comparative aspects, including the zoonotic potential, of enteric and respiratory viruses (coronaviruses, rotaviruses and caliciviruses) of food animals and humans. A related focus is mucosal immunity to these viruses and vaccine development. Our laboratory discovered the gut-mammary immunologic axis, a new concept leading to recognition of a common mucosal immune system in animals and humans. We exploited this concept to design vaccination approaches to prevent enteric viral infections of neonates. We continue to elucidate the immunologic interrelationships, T and B cell memory responses and maternal antibody impact among distinct mucosal tissues to devise new vaccine strategies for neonates. A current emphasis is on bioengineering of rotavirus-like-particle vaccines with immunomodulators to prevent rotavirus diarrhea, a leading cause of morbidity in young animals and mortality in infants. Our lab discovered, characterized and developed novel cultivation methods and diagnostic assays for new fastidious enteric viruses including group C rotavirus, a bovine torovirus and porcine and bovine enteric caliciviruses. Using our recently developed infectious viral clones, we are pursuing the genetic basis for in vitro replication and in vivo virulence of enteric caliciviruses. This research should unlock new avenues of investigation for uncultivable human caliciviruses, leading causes of food-borne illness worldwide. Besides comparative pathogenesis studies of animal and human enteric viruses in gnotobiotic animals, we are also investigating their antigenic and genetic relationships to assess their zoonotic potential and mechanisms for interspecies transmission and disease exacerbation

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