Marc Feldmann

University of Oxford


Election Year: 2010
Primary Section: 43, Immunology and Inflammation
Secondary Section: 41, Medical Genetics, Hematology, and Oncology
Membership Type: Foreign Associate

Research Interests

Having trained in Medicine and Immunology, my major interests have been to explore the mechanisms of human autoimmune diseases. My hypothesis that upregulated antigen presentation and elevated cytokine expression were important in the pathogenesis of autoimmune diseases, led to a productive collaboration with Professor Sir Ravinder Maini which has elucidated the importance of TNFa in rheumatoid arthritis. This was established using cultures of human diseased synovium, in animal models and in clinical trials, and has led to TNF blockade therapy being standard care for several rheumatoid arthritis.

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