Jue Chen
The Rockefeller University
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Primary Section: 29, Biophysics and Computational Biology Secondary Section: 23, Physiology and Pharmacology Membership Type:
Member
(elected 2019)
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Biosketch
Jue Chen is a structural biologist and biochemist who focuses her research on ATP-driven transporters. She received her Bachelor of Science in Chemistry from Ohio University, and Ph.D. in biochemistry from Harvard University, where she was advised by Dr. Don C. Wiley. She completed her postdoctoral work at Baylor College of Medicine with Dr. Florante A. Quiocho. In 2002, she joined Purdue University as assistant professor, was promoted to associate professor in 2007, and professor in 2011. Dr. Chen was named a Pew Scholar in 2003 and a Howard Hughes Medical Institute Investigator in 2008. In 2014, she joined the faculty of Rockefeller University, where she is now the William E. Ford Professor and Head of Laboratory of Membrane Biology and Biophysics. She was elected to the National Academy of Sciences in 2019.
Research Interests
Dr. Chen's research program began with a complete analysis of the structure and mechanism of the bacterial maltose transporter, a nutrient importer that has been extensively studied for more than 40 years as a prototype for ABC transporters. More recently, her laboratory has made major advances in several medically important ABC transporters, including the multidrug transporters P-glycoprotein and MRP1, TAP (the transporter associated with antigen processing), and CFTR (the cystic fibrosis transmembrane regulator). Their studies uncovered cross-cutting structural principles that underlie how nature utilizes the chemical energy of ATP hydrolysis to perform work-transporting substrates against their chemical gradients.
