Stephen L. Mayo

California Institute of Technology

Election Year: 2004
Primary Section: 29, Biophysics and Computational Biology
Secondary Section: 21, Biochemistry
Membership Type: Member

Research Interests

The focus of the lab has been the coupling of theoretical, computational, and experimental approaches for the study of structural biology. In particular, we have placed a major emphasis on developing quantitative methods for protein design with the goal of developing a fully systematic design strategy that we call "protein design automation." Our design approach has been captured in a suite of software programs called ORBIT (Optimization of Rotamers By Iterative Techniques) and has been applied to a variety of problems ranging from protein fold stabilization to enzyme design.

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