J. Richard McIntosh

University of Colorado Boulder

Election Year: 1999
Primary Section: 22, Cellular and Developmental Biology
Secondary Section: 29, Biophysics and Computational Biology
Membership Type: Member

Research Interests

I have worked to understand the mechanisms by which cells change their shapes and rearrange their internal components. In particular, I have studied the "mitotic spindle," i.e., the machinery that organizes and segregates the chromosomes in preparation for cell division. This work has included light and electron microscopy to characterize the structure of the mitotic spindle-the orientations, lengths, and relative positions of the microtubules, as well as the changes in structure that accompany chromosome segregation. My laboratory has also identified and studied several of the motor enzymes that consume biological fuel to generate the forces that segregate the chromosomes, generally with great reliability. We are now using electron tomography for detailed study of key spindle components, such as the sites of chromosome attachment to the spindle microtubules.

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