Howard M. Grey

La Jolla Institute for Allergy and Immunology

Election Year: 1999
Primary Section: 43, Immunology and Inflammation
Membership Type: Member

Research Interests

My principal research is the study of the mechanisms of foreign antigen recognition by the immune system. In the past, this involved the characterization of the immunoglobulin antigen receptors on the surface of B cells and, subsequently, the establishment of the B cells as antigen-presenting cells and their importance in the T cell-B cell interaction that results in the differentiation of B cells into antibody-secreting cells. More recently, my efforts have concentrated on the mechanisms of antigen recognition by T lymphocytes, in particular, the derivation of short peptides from complex protein antigens that are the relevant structures recognized by T cells. Currently, I am studying the capacity of low-affinity antigen analogs to act as T cell receptor antagonists and am investigating intracellular signals induced by these TCR antagonists and whether they are responsible for the inhibition of activation by antigenic peptides.

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