David J. DeRosier

Brandeis University

Primary Section: 29, Biophysics and Computational Biology
Secondary Section: 22, Cellular and Developmental Biology
Membership Type: Member (elected 2003)


David DeRosier received his BS (physics, 1961) and his PhD (biophysics, 1965) from the University of Chicago. From 1965-9 he was a postdoc with Aaron Klug (MRC LMB, Cambridge, England). He and Klug introduced the reconstruction of three-dimensional images from electron micrographs and applied it to the T4 phage tail. With RA Crowther and LA Amos, they generated the first single particle reconstructions of two icosahedral viruses. In 1969 DeRosier became assistant professor of chemistry (University of Texas, Austin). In 1973, he became associate professor of physics and in 1979, professor of biology (Brandeis University). He developed methods of image analysis applying them to actin and the bacterial flagellum. He retired in 2005 but continued research in super-resolution light microscopy with Professor Turrigiano (Brandeis).  In 2015, he became visiting scientist in the Hanein/Volkmann labs in San Diego, CA. DeRosier received the Elisabeth Roberts Cole Award (Biophysical Society), the Hollaender Award (National Academy of Sciences), and the Distinguished Scientist Award (The Microscopical Society). He is a fellow of the Biophysical Society, the American Academy of Microbiology, the American Association for the Advancement of Science, the American Academy of Arts and Sciences, and the National Academy of Sciences.

Research Interests

David DeRosier's current research is in the field of cryo-fluorescence microscopy combined with cryo-electron microscopy and image analysis.

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