Samuel J. Danishefsky
Memorial Sloan-Kettering Cancer Center
Election Year: 1986
Primary Section: 14, Chemistry
Membership Type: Member
My research includes the synthesis of substances of complex structure with interesting biological activity; new synthetic strategies of applicability not only to such target systems, but to general problems in synthesis; degree of stereochemical control which can be exercised; the understanding of the origins of diastereofacial and topographic selectivity are of continuing interest. Some examples are: taxol, calicheamicin, dynemicin, staurosporine, FR-900482 (a complex mitomycinoid), tryprostatin, N-acetylardeemin, a human breast tumor antigen, a human gastric cancer antigen, asparagine linked glycopeptides (ABO blood group antigens).