Charles Yanofsky

Stanford University

Election Year: 1966
Primary Section: 26, Genetics
Secondary Section: 44, Microbial Biology
Membership Type: Member

Research Interests

We are studying the mechanism of trytophan induction of expression of the tryptophanase operon of Escherichia coli and other bacterial species. During induction, synthesis of a tryptophan-containing leader peptide specified by the transcript of the operon interferes with Rho-dependent termination. We are also studying regulation of transcription termination in the tryptophan operon of Bacillus subtilis. In this operon, regulation is mediated by a tryptophan-activated RNA binding protein. The activity of this protein is influenced by uncharged tryptophan transfer RNA. Current studies are directed towards explaining this observation. Regulatory studies also are being performed with the fungus Neurospora crassa. Our objective is to determine the sequence of regulatory events that are responsible for the development of asexual spores by this organism.

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