Andrew Streitwieser, Jr.

University of California, Berkeley

Primary Section: 14, Chemistry
Membership Type: Member (elected 1969)

Research Interests

The reactions of salts of carbonyl compounds (e.g., lithium enolates) are important for modern synthetic organic chemistry. These salts are usually aggregated in nonpolar solvents and my group has been determining the role of such aggregates in synthetic reactions by careful study of equilibria and kinetics. The results are showing that lithium and cesium enolate monomers are much more reactive than aggregates in alkylation reactions and in some carbonyl reactions. Only in reactions with esters where the two oxygens can coordinate to two lithiums within an aggregate are the aggregates competitive with monomers. Other experimental research activities involve the preparation and study of enantiospecific catalysts. Theoretical studies using ab initio computations provide additional understanding of structures and reactions in organic and organometallic chemistry.

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