Ira Pastan
National Institutes of Health
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Primary Section: 41, Medical Genetics, Hematology, and Oncology Secondary Section: 42, Medical Physiology and Metabolism Membership Type:
Member
(elected 1982)
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Research Interests
My interest is in developing new therapies for cancer by making fusion proteins composed of the Fv portion of antibodies directed at antigens on cancer cells fused to a genetically modified form of a powerful bacterial toxin, Pseudomonas exotoxin A. These chimeric proteins which are termed recombinant immunotoxins are being tested in humans with various forms of cancer. I also study the human multidrug resistance gene, MDR1, and how this resistance gene can be used in gene therapy.
