Johann Deisenhofer

The University of Texas Southwestern Medical Center


Election Year: 1997
Primary Section: 29, Biophysics and Computational Biology
Membership Type: Member

Research Interests

We study the three-dimensional structures of biological macromolecules with the methods of x-ray crystallography. Our results enhance our understanding of the function and the structural stability of these molecules; they extend the database of known structures, which has become a most valuable resource for biomedical research. Among the techniques we use are heterologous expression, purification, crystallization, and mutagenesis of proteins, x-ray diffraction, computational crystallography, and structure analysis. Our interests focus on the following main areas: proteins involved in energy transfer and electron transfer, proteins using light energy, membrane proteins, membrane associating proteins, chaperonins, and proteins with repeating sequence motifs. Among the structures we determined during the last ten years are two cytochromes P450, the adenovirus type 5 knob protein, porcine ribonuclease inhibitor and its complex with bovine ribonuclease A, DNA photolyase and GroES from E. coli, gp31 (a viral homolog of GroES), human cpn10, SecA protein, the murine MHC Class I molecule H2-M3, the C-domain of bovine synapsin I, and the cytochrome bc1 complex from bovine heart mitochondria.

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