Gertrud M. Schupbach

Princeton University

Election Year: 2005
Primary Section: 22, Cellular and Developmental Biology
Secondary Section: 26, Genetics
Membership Type: Member

Research Interests

Signaling through the ERK pathway regulates many important steps in development. The Schupbach laboratory has studied the EGF receptor in Drosophila oogenesis which is involved in setting up the anterior posterior and dorso ventral axis of the egg and embryo. They determined how a localized signal within the oocyte activates the receptor in a spatially restricted area, and how this localized signal depends on RNA localization and translational control, including in put from a meiotic checkpoint that measures DNA damage as well as retrotransposon activity. The Schupbach laboratory has also studied the polarized secretion of extracellular matrix by the follicle cell epithelium, and the effects of Notch signaling on axis formation. More recently Schupbach has collaborated with the laboratory of Stas Shvartsman at Princeton University in more quantitative approaches to signaling in early embryos of Drosophila, using Drosophila as model system for human mutations in the Ras/Erk pathway.

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