Genetic Basis of Variation in Behavior, Evolution, and Disease
2011 Indo-American Symposium
J. Craig Venter Institute
February 2011 marks a decade since the publication of the Human Reference Genomes. Driven by technological advances in whole genome analysis (from genotyping to genome sequencing), the sequences of many additional genomes and model organisms have made it possible to use this information to determine the genome information impacts the underling basic biological properties such as development, behavioral differences, evolution of populations, and susceptibility to disease. In the next ten years, the scientific community looks forward to making advances in these areas. One of the major tasks will be adequate correlation of genotype-phenotype data, from the molecular level such as gene expression to complex organizational behavior. Technical advances in genome sequencing is allowing for new ways to look at genomes that was previously not possible. Immediate needs from additional reference genomes, defining the true extent of human variation versus sequencing error, to technical advances to define variation beyond the single nucleotide level and beyond the nuclear genome will be discussed in relevance to human disease, behavior and evolution.
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