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 Symbioses becoming permanent:
 The origins and evolutionary
 trajectories of organelles

This colloquium was held October 15-17, 2014 in Irvine, CA.  Organized by W. Ford Doolittle (Dalhousie University), Patrick Keeling (University of British Columbia), and John McCutcheon (University of Montana), the meeting was co-sponsored by Canadian Institute for Advanced Research


This colloquium had a goal of filling the gap between ‘endosymbiont’ and ‘organelle’ by identifying two experimental areas, Genome Evolution, and Integration and Control, where substantial advances have been made in both endosymbiont and organelle systems, but where the full potential of these advances has not been met due to the absence of a comparative framework. The Genome Evolution theme addressed issues of genome reduction and the relationship between genomic architecture and sequence evolution. The Integration and Control theme focused on processes through which two previously independent evolutionary individuals come to work together, such as gene flow, protein trafficking, signaling and transporters.



October 15, 2014
Distinctive Voices Public Lecture presented by Michael Gray, CIFAR Advisor, Dalhousie University, Making One from Two (or More): Mergers, Acquisitions, Downsizing and Innovation in Eukaryotic Cell Evolution

October 16, 2014
Introduction and welcome remarks – W. Ford Doolittle & Patrick Keeling

Theme 1: Genomes (evolutionary rates, oddities, and reduction)
Chair:  Toby Keirs

John McCutcheon, University of Montana, Endosymbiont genomes: from big to small to big again

John Archibald, Dalhousie University, Nuclear organelles

Andrew Roger,  Dalhousie University, Organelle reduction

Siv Andersson, Uppsala University, Alphaproteobacterial genome evolution

David Smith, University of Western Ontario, Roots of genomic architecture variation

Daniel Sloan, Colorado State University, Cytonuclear co-evolution under extreme mitochondrial mutation rates

John Allen, University College London, Why keep genomes?

Theme 2: Integration/Control (trafficking, signaling, transporters)
Chair: Dan Sloan

Patrick Keeling, University of British Columbia, The process of integration

Nancy Moran, University of Texas, Austin, Insect endosymbionts

Geoff McFadden, University of Melbourne, Diversity of protein trafficking

Chris Howe, Cambridge University, Why integrate?

Poster Session

October 17, 2014

Alex C.C. Wilson, University of Miami, Mechanisms of integration with focus on amino acid biosynthesis in the A. pisum/Buchnera holosymbiont

Steve Perlman, University of Victoria, Maternal transmission, sex ratio distortion, and mitochondria

William Martin, Düsseldorf University, Endosymbiont and organelle, what’s the difference?

Moriya Okhuma, Riken University, Metabolic integration across endosymbiotic communities

Debashish Bhattacharya, Rutgers University, Transporters in organellogenesis

Theme 3: Theories and Models
Chair: W. Ford Doolittle

Toby Kiers, University Amsterdam, Bacterial cooperativity

Marc Ereshefsky, University of Calgary, Evolutionary individuality

Peter Godfrey-Smith, City University of New York, Individuality and the egalitarian transitions

Maureen O’Malley, University of Sydney, Philosophical Reflections on Endosymbiosis: Implications for Evolutionary Theory





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