A Library Approach to Chemistry and Biology
Organized by Peter Schultz
October 20-21, 1997
Irvine, CA
Monday, October 20
Peter G. Schultz and Jonathan Ellman, Introductory Remarks
Session One: Catalysis
Catalytic Antibodies
Richard A. Lerner, The Scripps Research Institute
Reducing Big Molecules to Smaller Ones
Jim Wells, Genentech, Inc.
In vitro Selection and Evolution of RNA, DNA and Proteins
Jack W. Szostak, Harvard Medical School/Mass. General Hospital
Session Two: Protein Structure and Function
Molecular Breeding of Enzymes, Pathways and Viruses by Recursive Sequence Recombination
Willem P.C. Stemmer, Maxygen, Inc.
Unnatural Natural Products: From Multifunctional Enzymology to Drug Discovery
Sequence Determinants of Protein Folding and Function
Robert T. Sauer, Massachusetts Institute of Technology
Session Three: Biomolecular Recognition
Cell Surface Receptor Ligands Identified From Combinatorial Libraries
Ronald W. Barrett, Affymax Research Institute
Combinatorial Synthesis and the Sequence-Selective Binding of Peptides
W. Clark Still, Columbia University
Tuesday, October 21
Session Three: Biomolecular Recognition (cont.)
Discovery of Ligands for Use in Chemical Genetics
Stuart L. Schreiber, Harvard University
Session Four: Drug Discovery
Computer Aided Combinatorial Design
Tack Kuntz, University of California, San Francisco
Fluorescent Chemosensors of Intracellular Signal Transduction for High-throughput Functional Screening
Roger Y. Tsien, University of California, San Diego
Maximizing Drug Targets with Yeast Genetics
Jasper Rine, University of California, Berkeley
Session Five: New Frontiers
Genes, Chips and the Human Genome
Stephen P.A. Fodor, Affymetrix
Searching Peptide Space for Cell-Targeting Peptides
Stephan Albert Johnston, University of Texas-Southwestern Medical Center
Combinatorial Methodologies for Materials Discovery
Henry Weinberg, Symyx Technologies
