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A Library Approach to Chemistry and Biology

Organized by Peter Schultz

October 20-21, 1997
Irvine, CA

Monday, October 20
Peter G. Schultz and Jonathan Ellman, Introductory Remarks

Session One: Catalysis

Catalytic Antibodies
Richard A. Lerner, The Scripps Research Institute

Reducing Big Molecules to Smaller Ones
Jim Wells, Genentech, Inc.

In vitro Selection and Evolution of RNA, DNA and Proteins
Jack W. Szostak, Harvard Medical School/Mass. General Hospital

Session Two: Protein Structure and Function

Molecular Breeding of Enzymes, Pathways and Viruses by Recursive Sequence Recombination
Willem P.C. Stemmer, Maxygen, Inc.

Unnatural Natural Products: From Multifunctional Enzymology to Drug Discovery

Sequence Determinants of Protein Folding and Function
Robert T. Sauer, Massachusetts Institute of Technology

Session Three: Biomolecular Recognition

Cell Surface Receptor Ligands Identified From Combinatorial Libraries
Ronald W. Barrett, Affymax Research Institute

Combinatorial Synthesis and the Sequence-Selective Binding of Peptides
W. Clark Still, Columbia University

Tuesday, October 21

Session Three: Biomolecular Recognition (cont.)

Discovery of Ligands for Use in Chemical Genetics
Stuart L. Schreiber, Harvard University

Session Four: Drug Discovery

Computer Aided Combinatorial Design
Tack Kuntz, University of California, San Francisco

Fluorescent Chemosensors of Intracellular Signal Transduction for High-throughput Functional Screening
Roger Y. Tsien, University of California, San Diego

Maximizing Drug Targets with Yeast Genetics
Jasper Rine, University of California, Berkeley

Session Five: New Frontiers

Genes, Chips and the Human Genome
Stephen P.A. Fodor, Affymetrix

Searching Peptide Space for Cell-Targeting Peptides
Stephan Albert Johnston, University of Texas-Southwestern Medical Center

Combinatorial Methodologies for Materials Discovery
Henry Weinberg, Symyx Technologies

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