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Genetic Engineering of Viruses and Viral Vectors

Organized by Peter Palese and Bernard Roizman

June 9-11, 1996
Irvine, CA

Sunday, June 9

Session One
Elliott Keiff, Chair

Site-Specific Integration by Adeno-Associated Virus
Kenneth I. Berns, Cornell University

Biology of Adenovirus Vectors
Thomas E. Shenk, Princeton University

A New Adenoviral Vector of High Capacity and Lacking Adenoviral Gene Expression
C. Thomas Caskey, Merck

Gene Therapy for Metastatic Disorders with Recombinant Viral Vectors
Savio L.C. Woo, Baylor College of Medicine

Session Two
Kenneth I. Berns, Chair

Gene Content and Genetic Engineering of Herpes Simplex Viruses
Bernard Roizman, University of Chicago

The Application of Genetically Engineered Herpes Simplex Virus for the Treatment of Brain Tumors
Richard J. Whitley, University of Alabama

Replication-Defective HSV Vectors for Gene Transfer In Vivo
Joseph C. Glorioso, University of Pittsburgh

Expression of Latent Cytomegalovirus Genes in Hematopoietic Progenitors
Edward S. Mocarski, Stanford University

Research Effects of Human Cytomegalovirus Early Glycoprotein on MHC Class I Heavy Chains
Thomas R. Jones, Wyeth-Ayerst

Monday, June 10

Session Three
Inder M. Verma, Chair

Genetic Engineering of Influenza Viruses
Peter Palese, Mount Sinai School of Medicine

Assembly of New Envelopes on VSV Vectors
John K. Rose, Yale University

Infection of Target Cells by Rhabdovirus Vectors Possessing Heterologous Spike Glycoproteins
Karl-Klaus Conzelmann, Federal Research Center for Virus Diseases of Animals, Tubingen

Alpha Virus-Based Expression Vectors: Strategies and Applications
Charles M. Rice, Washington University

Early Events in Poliovirus Infection: Virus-Receptor Interactions
Vincent R, Racaniello, Columbia University

Session Four
Thomas E. Shenk, Chair

Retroviral Vectors: Targeting and Transduction of Non-Dividing Cells
Inder M. Verma, Salk Institute

Genetic Manipulation of the Nef Locus of SIV and HIV
Ronald C. Desrosiers, Harvard Medical School

Development of HIV Vectors for HIV Gene Therapy
Flossie Wong-Staal, University of California, San Diego

Evolution and Application of Retroviral Vectors
Richard C. Mulligan, Whitehead Institute of Biochemical Research

Cell-Surface Receptors for Retroviruses and Implications for Gene Transfer
A. Dusty Miller, Fred Hutchinson Cancer Center

Tuesday, June 11

Session Five
Bernard Moss, Chair

EBV Genomes Capable of Maintaining 100kbp of Foreign DNA as Episomes in Immortal Cell Lines
Elliott Kieff, Harvard Medical School

Genetically Engineered Poxviruses and Their Uses for Gene Expression and Vaccination
Bernard Moss, National Institutes of Health

Application of Poxvirus Vectors to Vaccination: An Update
Enzo Paoletti, Virogenetics

DNA Vaccines: Plasmid DNA as a Delivery System
Margaret A. Liu, Merck

Fusigenic Viral-Liposome for Gene Therapy in Cardiovascular Disease
Victor J. Dzau, Stanford University

Concluding Remarks

Support From The Following Companies is Gratefully Acknowledged:
Bristol-Meyers Squibb

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