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The Biology of RNAi

Organized by Phillip Sharp and Andrew Fire

May 17-18, 2004
Washington, DC

Meeting Overview:
As you will see from the scientific presentations at this meeting, the ability to silence genes "at will" through the use of a double stranded RNA trigger has provided biologists with a combination of useful tools and perplexing biological questions. The mechanisms that underlie cellular responses to double stranded RNA, the conditions under which these mechanisms are utilized by cells, and the ways in which the system is used to provide biological control are all exciting and open issues in Biology.

Andrew Fire, Stanford University School of Medicine, Organizer
Introduction and Overview: RNAi as Biology

Session I: Short RNAs as Genetic Regulators

Classes of Small RNAs Carrying out Widespread Gene Silencing in C. Elegans
Victor Ambros, Dartmouth University, Chair

RNAi and Development in C. Elegans
Craig Mello, University of Massachusetts Medical School

Evolution and Mechanism of RNAi: Insights from Protozoan Parasites
Elisabetta Ullu, Yale University

MicroRNAs and Their Regulatory Roles
David Bartel, Whitehead Institute and Massachusetts Institute of Technology

Asymmetric Assembly of the Rnai Enzyme Complex
Phillip Zamore, University of Massachusetts Medical School

Session II: Short RNAs in Epigenetic Regulation and Immunity

Viral Suppression of RNA Silencing: The Role of Small Regulatory RNAs
Vicki Vance, University of South Carolina, Chair

Short RNA in Transgene and Sine Element Silencing
David Baulcombe, Sainsbury Laboratory of the John Innes Centre

RNAi-Mediated Epigenetic Control of the Genome
Shiv Grewal, Laboratory of Molecular Cell Biology, National Cancer Institute, NIH

De novo DNA Methylation of Transformed Direct Repeats Mediated by RNA Silencing
Steve Jacobsen, University of California, Los Angeles

RNAi in Genome Rearrangement and Centromere Function in Tetrahymena
Martin Gorovsky, University of Rochester

Session III: Widening Roles for RNA-based Regulation

RNAi and Transposon Silencing in C. Elegans
Ron Plasterk, Netherlands Institute for Developmental Biology, Chair

Sense and Antisense RNAs in the Regulation of X-chromosome inactivation
Jeannie Lee, Harvard Medical School

The Intersection of RNA Editing and RNA Interference
Anastasia Khvorova, Dharmacon, Inc.

Genetic Control by Riboswitches and Ribozymes
Ron Breaker, Yale University

Transcriptional and Posttranscriptional Gene Regulation by dsRNA-derived Small RNAs
Tom Tuschl, The Rockefeller University

Session IV: Implications and Applications of RNAi
Peter Linsley, Rosetta Inpharmatics, Chair

Speaker: Cynthia Kenyon, University of California, San Francisco

Identification of Novel Cancer-relevant Genes using RNA Interference
René Bernards, Netherlands Cancer Institute

Summary and Perspectives
Phillip Sharp, Massachusetts Institute of Technology, Organizer

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