The Neurobiology of Pain
Organized by Ronald Dubner and Michael Gold
December 11-13, 1998
Irvine, CA
Friday, December 11
Introduction, Ronald Dubner, Colloquium Organizer
Session I: Channels
John Hunter, Department of Analgesia, Roche Bioscience, Chair and Discussion Leader
Sodium Channels and the Pathophysiology of Pain
Stephen G. Waxman, Department of Neurology, Yale University School of Medicine
TTX-R INa and Inflammatory Hyperalgesia
Michael Gold, Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School
Which Potassium Channels Keep Vagal Afferent Neurons Mellow?
Daniel Weinreich, Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine
Heat-Activated Ion Currents in Nociceptors Transduction and Sensitization
Peter McNaughton, Department of Physiology, King's College London, Discussant
Session II: Receptors
Patrick Mantyh, Department of Prev. Sciences, University of Minnesota, Chair and Discussion Leader
AMPA and Kainate Receptor Expression by DRG Neurons in Culture
Amy B. MacDermott, Department of Physiology and Cellular Biophysics and Center for Neurobiology and Behavior, Columbia University
The Role of Sensory Modality-Selective Gene Transcription in Opioid Analgesia
Edwin W. McCleskey, Vollum Institute, Oregon Health Sciences University
NMDA Receptors and Src in Synaptic Plasticity
Michael W. Salter, Programmes in Brain and Behavior and Cell Biology, Hospital for Sick Children, and Department of Physiology, University of Toronto
Receptor Expression and Regulation as Mechanisms Underlying Pain and Pain Pathology
Edward R. Perl, Department of Physiology, University of North Carolina School of Medicine, Chapel Hill, Discussant
Saturday, December 12
Michael Gold, Colloquium Organizer, Introduction
Gregory Terman, Department of Anesthesiology, University of Washington, Seattle, Tribute to John Liebeskind
Session III A: Systems and Imaging
Donna Hammond, Anesthesia and Critical Care, University of Chicago, Chair and Discussion Leader
Evidence for a Visceral Pain Pathway in the Dorsal Column of the Spinal Cord
William D. Willis, Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, Texas
The Spinal Biology in Humans and Animals of Pain States Generated by Persistent Small Afferent Input
Tony L. Yaksh, Anesthesiology Research Laboratory, University of California
Gerald Gebhart, Department of Pharmacology, University of Iowa, Discussant
Session III B: Systems and Imaging
James Campbell, Department of Neurology, Johns Hopkins University Medical School, Chair and Discussion Leader
Neuropeptides and Brainstem Pain Modulating Circuits
Howard Fields, University of California, San Francisco
Forebrain Mechanisms of Nociception and Pain: Analysis Through Imaging
Kenneth L. Casey, Neurological Service, Veterans Administration Medical Center, Ann Arbor, Michigan
What Are the Essential Cerebral Components?
M. Catherine Bushnell, McGill University, Montreal, Discussant
Session IV: Growth Factors and Cytokines
Kenneth Hargreaves, Department of Endodontics, University of Texas Health Sciences Center, Chair and Discussion Leader
Trophic Factor Regulation of Nociceptor Development
William Snider, Department of Neurology, Washington University Medical Center
Neurotrophins and Pain
Lorne M. Mendell, Department of Neurobiology and Behaviour, State University of New York at Stony Brook
Immune-to-Brain Communication: Implications for Sickness and Pain
Linda R. Watkins, Department of Psychology, University of Colorado at Boulder
Multiple Trophic Factor Influences on Nociceptive System
Stephen B. McMahon, Neuroscience Research Centre, King's College London, Discussant
Session V: Development and Plasticity
Ronald Dubner, Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Chair and Discussion Leader
Postnatal Changes in Dorsal Horn Cell Activity The Development of Spinal Sensory Processing
Maria Fitzgerald, Department of Anatomy and Developmental Biology, University College London
Signal- and Activity-Dependent Plasticity in the Somatosensory System - Unraveling the Cellular and Molecular Mechanisms of Pain
Clifford J. Woolf, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School
Cellular Mechanisms of Hyperalgesia and Morphine Tolerance and Their Interactions
David J. Mayer, Department of Anesthesiology, Medical College of Virginia
The Revolution in Pain Research
Gary Bennett, Department of Neurology, Allegheny University, Philadelphia, Discussant
John Loeser, Department of Neurological Surgery and Anesthesiology, University of Washington Medical Center, Banquet Speaker
Sunday, December 13
Session VI: Molecular Genetics
Charles Inturrisi, Department of Pharmacology, Cornell University Medical College, Chair and Discussion Leader
The Neurochemistry of Acute and Persistent Pain
Allan Basbaum, Department of Anatomy, University of California, San Francisco
Migraine Pathophysiology and Treatment Mechanisms
Michael A. Moskowitz, Department of Neurosurgery and Neurology, Massachusetts General Hospital
The Genetics of Pain and Pain Inhibition: From Mice to Molecules
Jeffrey Mogil, Department of Psychology, University of Illinois at Urbana
The Mu Opiate Receptor as a Model Gene for Individual Differences in Pain and Pain Modulation
George Uhl, National Institute on Drug Abuse, National Institutes of Health
Antisense Oligodeoxynucleotides Against the TTX-Resistant Sodium Channel, PN3, Prevent and Reverse Chronic, Inflammatory and Neuropathic Pain in the Rat
Discussant Frank Porreca, Department of Pharmacology, University of Arizona Health Sciences Center
