Anthony A. Kossiakoff is the Otho S.A. Sprague Distinguished Service Professor in the Department of Biochemistry and Molecular Biology at the University of Chicago. He earned his BS in Chemistry and Mathematics at Davis and Elkins College and his Ph.D in Physical Chemistry at the University of Delaware. He was a postdoctorial fellow in structural biology at the California Institute of Technology. He then joined the faculty of the Biology Department at Brookhaven National Laboratory in 1975 where he worked in the area of neutron diffraction of proteins. In 1983 he joined Genentech as Director of Biocatalysis. He subsequently helped establish the Protein Engineering Department and served as its Director from 1986- 1998. In 1998 he moved to the University of Chicago in the Department of Biochemistry and Molecular Biology and served as Chair from 1998 to 2012. He also served as the Director of the Institute of Biophysical Dynamics at the University of Chicago from 1998- 2003. He was elected as a Fellow of the American Association for the Advancement of Science in 2012. He received the Anfinsen Award from the Protein Society recognizing contributions in technology development in protein science. He is a member of the alumni Hall of Fame at the University of Delaware and was conferred an Honorary Degree in Science by Davis and Elkins College.

Research Interests

Research interests focus on the structure-function and energetic interrelationships defining the molecular recognition processes that trigger and regulate biological processes. These relationships are addressed using a combination of tools and techniques including protein and antibody engineering, structural biology, directed evolution, synthetic biology, biophysical analyses and cell biology. Developing tools to study functional transient conformational states by structural biology based on customized synthetic antibodies. Methods to enable structure determination of small protein systems by cryo-EM. Receptor-mediated drug delivery. Immuno-based bio-therapeutics: T-cell engineering, engineering universal CARTs systems and plug and play bispecific T-cell engagers.

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Primary Section

Section 29: Biophysics and Computational Biology

Secondary Section

Section 21: Biochemistry