Research Interests

I have been interested in the problem of how proteins are degraded in cells in a selective and regulated fashion. By the use of biochemical approaches, it was found in my laboratory that proteins are marked for degradation by attachment to a small protein, called ubiquitin. We have furthermore discribed several enzymes which catalyze biochemical reactions of the ubiquitin system for protein degradation. The most important of these are ubiquitin-protein ligases, or E3 enzymes, which recognize specific features in certain proteins and target them for degradation at the right time. More recently, I am investigating the roles of several ubiquitin-protein ligases in the control of cell division. Recent work in many laboratories has shown that ubiquitin-mediated protein degradation is involved in many basic biological processes, such as the control of cell proliferation, signal transduction, development, the immune response and the inflammatory response.

Membership Type

International Member

Election Year


Primary Section

Section 21: Biochemistry