Charles C. Richardson

A major goal is to define, in molecular terms, the mechanism by which a large duplex DNA molecule is replicated. The replication of the chromosome of bacteriophage T7 has been used as a model system. Emphasis is focused on the protein-protein and protein-DNA interactions responsible for the coordination of events at the origin of replication and at the replication fork. Studies on initiation of DNA replication focus on the role of each of several elements located in the primary origin of replication.