Biosketch
David Case received his undergraduate education from Michigan State University, and earned Masters and Ph.D. degrees from Harvard University, working with Dudley Herschbach and Martin Karplus. He has held teaching positions at the University of California, Davis, The Scripps Research Institute, and at Rutgers University.
Awards include the President’s Award from the International Society for Quantum Biology and Pharmacology; the American Chemical Society Award for Computers in Chemical and Pharmaceutical Research; and elected membership in the Royal Society of Chemistry (U.K.) and the National Academy of Sciences (U.S.).
Research Interests
Research interests largely flow from molecular dynamics (MD) simulations of proteins and nucleic acids, and on its associated computational infrastructure. Case has overseen the popular Amber suite of codes for biomolecular simulation, and has contributed to the underlying potential energy functions, and to implicit solvent models that mimic the effects of water and ions surrounding macromolecules.
Applications have focused on the interpretation of nuclear magnetic resonance (NMR) spectroscopy, revealing the origins of time-dependent relaxation in such systems, leading to atomic models for structure and dynamics. Other NMR research interests include analyses of chemical shifts and spin-spin coupling constants. More recent efforts have made` use of MD models in the interpretation of Xray crystallography and cryo-electron microscopy experiments.
Membership Type
Member
Election Year
2025
Primary Section
Section 29: Biophysics and Computational Biology
Secondary Section
Section 14: Chemistry