Biosketch
Kelly Chibale is a full Professor of Organic Chemistry at the University of Cape Town (UCT) where he holds the Neville Isdell Chair in African-centric Drug Discovery & Development. He is also a Schmidt Sciences AI2050 Senior Fellow, Full Member of the UCT Institute of Infectious Disease & Molecular Medicine, founding Director of the South African Medical Research Council Drug Discovery & Development Research unit at UCT, Founder & Director of the UCT Holistic Drug Discovery and Development (H3D) Centre, and Founder & CEO of the H3D Foundation. He obtained his PhD in Synthetic Organic Chemistry from the University of Cambridge. This was followed by postdoctoral stints at the University of Liverpool and at The Scripps Research Institute. He was a Sandler Sabbatical Fellow at the University of California San Francisco, a US Fulbright Senior Research Scholar at the University of Pennsylvania School of Medicine, and a Visiting Professor at Pfizer. He is an Honorary Fellow of Queens’ College at the University of Cambridge and a member of the National Academy of Medicine and the NAS. Awards include a South African Medical Research Council Gold Medal and Royal Society (UK) Africa Prize.
Research Interests
Dr Chibale’s research interests are in infectious disease drug discovery and the development of technologies to contribute to improving treatment outcomes in people of African descent. The drug discovery research focuses on the causative agents of malaria (Plasmodium falciparum), tuberculosis (Mycobacterium tuberculosis) and antibiotic-resistant microbial diseases (ESKAPE pathogens). The research integrates chemistry, biology and pharmacology, including drug metabolism and pharmacokinetics, to identify preclinical drug development candidates. As part of the programs, mechanism of action studies through target identification are also conducted. Within the context of development of technologies to contribute to improving treatment outcomes in people of African descent, pharmacogenomics research is conducted in terms of evaluating the impact of variable genetics on drug pharmacokinetics in African populations. Artificial intelligence (AI) and machine learning are used in the drug discovery programs and coupled to pharmacometrics modelling to tailor drug dosages in pharmacogenomics research aspects.
Membership Type
International Member
Election Year
2025
Primary Section
Section 61: Animal, Nutritional, and Applied Microbial Sciences