Biosketch

Michael Diamond is a physician-scientist with research interests in virology and immunology and a focus on emerging RNA viruses including flaviviruses, alphaviruses, and coronaviruses. Dr. Diamond’s scientific accomplishments include the discovery of immune sensors that distinguish viral and host RNA, the generation of antibody therapeutics against multiple viruses, the delineation of immune mechanisms of control of viral infections, the identification of novel alphavirus entry receptors and their roles in viral tropism and pathogenesis, and the development and study of mucosal and intramuscular vaccines against SARS-CoV-2. Dr. Diamond was born in the borough of Queens in New York City and received his B.A. from Columbia University and M.D. and Ph.D. (in Cell and Developmental Biology) from Harvard Medical School and Harvard University. He completed his residency in Internal Medicine and fellowship in Infectious Diseases at the University of California, San Francisco and postdoctoral training at the University of California, Berkeley. He started his laboratory in 2001 at Washington University School of Medicine, where he is currently the Herbert S. Gasser Professor of Medicine, Molecular Microbiology, and Pathology & Immunology. In addition to his election to the National Academy of Sciences, he is an elected member of the American Society for Clinical Investigation, the Association of American Physicians, the American Academy of Microbiology, the American Association for the Advancement of Science, the National Academy of Inventors, and the National Academy of Medicine.

Research Interests

The Diamond laboratory investigates the molecular basis of infection and disease of globally emerging RNA viruses with a focus on the interface between pathogenesis and host immunity. His group studies positive-stranded RNA viruses from three important classes that infect humans: flaviviruses, alphaviruses, and coronaviruses. His laboratory develops and uses mouse models to identify mechanisms of viral immune evasion and host immune factors that restrict virus infection in different tissues. His group uses CRISPR-Cas9 screens to identify novel receptors required by viruses for entry, infection, tropism, and pathogenesis. His laboratory also has generated, characterized, and mapped thousands of mouse and human antibodies against flaviviruses (West Nile, Dengue, Zika, Powassan, yellow fever, and Japanese encephalitis viruses) alphaviruses (chikungunya, Mayaro, Venezuelan equine encephalitis, Eastern equine encephalitis, and Western equine encephalitis viruses), and coronaviruses (SARS-CoV-2) and studied their structure-function relationships to neutralization and Fc effector functions as well as their ability to prevent or treat infection and disease. His group developed mouse models of SARS-CoV-2 pathogenesis and used them to advance novel antibody-based therapeutics and mucosal vaccines, which are approved or in human clinical trials. His laboratory also investigates how trans-kingdom interactions (helminth co-infection, bacterial microbiota, and constituent metabolites) link with innate and adaptive immunity to modulate systemic viral infection and disease pathogenesis.

Membership Type

Member

Election Year

2024

Primary Section

Section 44: Microbial Biology

Secondary Section

Section 43: Immunology and Inflammation