Research Interests

RNA, the blueprint for proteins, is made in all cells by a complex molecular machine, the DNA-dependent RNA polymerase through a process called transcription. My research explores the mechanism and regulation of transcription, primarily in bacteria. We determine the three-dimensional structures of RNA polymerase and other associated proteins using X-ray crystallography and electron microscopy. We combine these studies with biophysical, biochemical, and genetic approaches to understand how transcription and, by extension, gene expression are controlled.

Membership Type


Election Year


Primary Section

Section 21: Biochemistry

Secondary Section

Section 29: Biophysics and Computational Biology