Timothy J. Richmond

My laboratory endeavors to reveal the hierarchal structure of chromatin at atomic resolution, and to apply the results to the elucidation of mechanisms of gene expression. Knowledge of chromatin structure is indispensable for an accurate description of nuclear processes including the propagation of epigenetic traits, and will consequently have substantial impact on the treatment and prevention of disease. I have chosen X-ray crystallography, and more recently, cryo-electron microscopy as the primary techniques to image chromatin. Continuing from our crystal structures of the nucleosome core and various transcription factor complexes, we are currently studying the chromatin fiber and interacting components such as chromatin remodeling factors.